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IRON METABOLISMThis research focus aims at the full understanding of iron metabolism, in particular the identification and characterization of novel factors that mediate dysregulation of iron homeostasis in various human disorders among which some of the world's most prevalent diseases such as anemia of chronic kidney disease, rheumatic diseases, hereditary hemochromatosis, iron loading anemia's, bacterial and malaria infections, cardiovascular disease and mild non-hereditary hepatic iron overload associated with alcohol abuse, hepatitis C infection and the metabolic syndrome. New findings are translated into novel diagnostic assays and therapeutic strategies that can be implemented in the clinic. Among our most recent achievements is the development of a mass spectrometry assay for the recently discovered iron regulatory hormone peptide hepcidin that is currently subject of several translational studies http://www.hepcidinanalysis.com/ Theme leaders: Prof. Dr. Dorine W. Swinkels and Dr. Mirian Janssen PhD Students: Tessel Gadesloot, Guus Kortman Research focus: regulation of iron homeostasis in health and disease | ||
