GLYCOSYLATION DISORDERS

Within the Glycosylation Disorders Group, we investigate the complex biosynthetic and catabolic pathways of glycans in health and disease with a clinical and biochemical focus on Congenital Disorders of Glycosylation (=CDG).

Glycosylation is a biochemical process of post-synthetic modification occurring on the majority of proteins and in all cell-types. In parallel with the development of novel analytic techniques, the research group applies a broad range of biochemical, genetic and cell biological methods to identify new disease entities, improve current diagnostics and for under­standing of pathophysiological mechanisms. These aspects are of prime importance for the development of future therapeutic strategies.

Dutch Society for Glycobiology http://www.glycobiology.nl
Nijmegen Glycobiology Platform www.glycobiologynijmegen.nl
Nijmegen Center for Disorders of Glycosylation www.nijmegencdg.nl
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Theme leader: Dr. Dirk Lefeber

Participants: Dr. Eva Morava, Prof. Dr. Ron Wevers

Postdoctoral fellow: Dr. Monique van Scherpenzeel

PhD Students: Ir. Mailys Guillard, Sharita Timal-Stevenson, Moniek Riemersma

Technicians: Ing. Karin Huijben, Irma Versleyen-Loe, Gerry Steenbergen-Spanjers